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New to Board - Hoping for Twins - Protocol help needed

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New to Board - Hoping for Twins - Protocol help needed

Postby kar1ene » Mon Jan 05, 2015 9:49 pm

Hi Ladies,
I am in the UK - 36
Looking for help really... I TTC twins about 6 years ago now, 1st cycle clomid only, BFN u/p Clomid only 2nd cycle and had my beautiful daughter. At the 8 week scan they noticed other follicles but they were under developed?. Anyways since then u/p drugs seems impossible to obtain and I do not trust transferring my money in to accounts abroad, I have managed to get some from a friend travelling abroad. I have Clomid and 3 Ovidrel injections (6,500 IU).

I began to have some irregular periods last summer where I have a 21 day cycle instead of usual around 28 days. I was sent for blood tests etc as my Mother had gone through menopause in her early 30s. Results came back fine - no hormone problems. Was then sent for a scan and they said I had PCOS - many cysts on the ovaries and may struggle to get pregnant. I do not know if this is due to the clomid years ago or if this was something that was going to happen anyways? My sister also TTC twins and had a singleton, she has a Cyst on her ovary. Just the one which flares up from time to time... Regardless of this I am still wanting to try for twins. My GP/Doctor believed that I would struggle to get pregnant in future and may need assistance? I wasn't worried about it at the time as it wasn't in my plan. However we went on holiday last August and I got pregnant, although AF showed her face a day or so later. So I don't believe my bodies not working?

I have been watching in on the boards on and off over the years. I am putting together a protocol - although any help advice, or thoughts would be greatly appreciated - I am hoping to get it right as obtaining more meds is impossible until August. I have been BBT charting and it appears I ovulate on CD17 although from what I have read this doesn't matter when you are taking clomid & trigger?? any advice gratefully received.

I plan to take:
Folic Acid - need to look in to the mg as this seems to be a common thing on everyones protocols ??advice??
Robitussen - daily to help with effects of Clomid
Clomid 3-7 (100mg) although considering alternating 50mg every other day?
?? CD10/11?? Ovidrelle Trigger 6,500 IU ?
From here on in, I am not sure where to go or what to do. I see that some people also trigger 5 DPO - although is that with the same drug? could I use ovidrel or need something else??
I was hoping to do progesterone cream also - but so far I cannot find anywhere in the UK to source

I would really appreciate any help or advice to help me put it together. Thank you in advance.
K
27th May 15 - AF CD5-8 100mg Clomid, CD9 50mg Robitussen 3 x daily + OPK CD 15 - Ovitrelle 250mg(6500IUI) FF said ovulated CD 17 AF arrived CD29 not normal for me.

25/6/15 - Clomid 100mg CD2 75mg CD3-5 - 100mg CD6 - +opk CD 12! Ovitrelle Trigger CD12(midnight) - Scan CD13 - 4 Dominant Folls - 9/7/15 currently 3DPO! Totally unexpected cycle so far!

http://www.fertilityfriend.com/home/23b5d1/
kar1ene
 
Posts: 60
Joined: Thu Dec 18, 2014 9:07 pm

Re: New to Board - Hoping for Twins - Protocol help needed

Postby Bluerose26 » Wed Jan 07, 2015 9:02 am

Yes you can do a booster shot with ovidrelle 5dpo, from what I understand you don't need the progesterone and booster shot, just one or the other
Image
CD1-BFP:
Folic acid 5mg
Pregnacare conception couple
Royal Jelly 500mg
CD1-O:
Evening primrose oil 1000mg x3 daily
CD2-CD7:
Clomid 25/50mg
CD5-CD6:
FSH 37.5iu. Folliculine/Bravelle
CD7-CD8-CD10:
FSH 75iu. Folliculine/Bravelle
5000 iu trigger (at positive opk)
1DPO-5DPO:
Bromalain (pineapple) 1500mg
1DPO-10weeks +:
Progesterone?
5DPO:
1-2000iu triggerx
Bluerose26
 
Posts: 25
Joined: Wed Nov 19, 2014 7:39 pm

Re: New to Board - Hoping for Twins - Protocol help needed

Postby kar1ene » Wed Jan 07, 2015 8:44 pm

Hi Blue Rose, thanks for your reply.

I have seen a lot of protocols similar to yours, you have a wide variety of items, can I ask why you have clomid and bravelle, I though they were similar?. I see you do a trigger on a positive OPK. From what I have read from a positive OPK, ovulation occurs within 24 hours?? I thought the triggers take 24-48 hours to work.. How did you determine the amount of trigger to use on OPK positive and 5dpo.
Thanks
27th May 15 - AF CD5-8 100mg Clomid, CD9 50mg Robitussen 3 x daily + OPK CD 15 - Ovitrelle 250mg(6500IUI) FF said ovulated CD 17 AF arrived CD29 not normal for me.

25/6/15 - Clomid 100mg CD2 75mg CD3-5 - 100mg CD6 - +opk CD 12! Ovitrelle Trigger CD12(midnight) - Scan CD13 - 4 Dominant Folls - 9/7/15 currently 3DPO! Totally unexpected cycle so far!

http://www.fertilityfriend.com/home/23b5d1/
kar1ene
 
Posts: 60
Joined: Thu Dec 18, 2014 9:07 pm

Re: New to Board - Hoping for Twins - Protocol help needed

Postby Bluerose26 » Thu Jan 08, 2015 4:20 pm

Short answer:
Clomid is to help encourage more eggs to be produced, bravelle is to help all the eggs to mature, its FSH so very different from clomid.
I'm actually tracking my ovulation with OPK's for a few months before actively ttct so I can make the best judgement I can on when to trigger. So I'm looking for the opk to be steadily approaching positive and will trigger before it gets to a full positive, so I will be testing several times a day.
In terms of the trigger, research shows 5000iu is recommended for women who are not overweight, if you are overweight you will want to use 10000iu trigger. And for a booster shot you should be looking at half the amount, or less, of your main trigger.
Hope this helps
Image
CD1-BFP:
Folic acid 5mg
Pregnacare conception couple
Royal Jelly 500mg
CD1-O:
Evening primrose oil 1000mg x3 daily
CD2-CD7:
Clomid 25/50mg
CD5-CD6:
FSH 37.5iu. Folliculine/Bravelle
CD7-CD8-CD10:
FSH 75iu. Folliculine/Bravelle
5000 iu trigger (at positive opk)
1DPO-5DPO:
Bromalain (pineapple) 1500mg
1DPO-10weeks +:
Progesterone?
5DPO:
1-2000iu triggerx
Bluerose26
 
Posts: 25
Joined: Wed Nov 19, 2014 7:39 pm

Re: New to Board - Hoping for Twins - Protocol help needed

Postby kar1ene » Thu Jan 08, 2015 7:28 pm

Thanks Blue Rose, I am still waiting till I have a protocol I am happy with before proceeding. Although am now wondering if Bravelle is something I should be bringing in to the protocol. Wishing you all the best,
27th May 15 - AF CD5-8 100mg Clomid, CD9 50mg Robitussen 3 x daily + OPK CD 15 - Ovitrelle 250mg(6500IUI) FF said ovulated CD 17 AF arrived CD29 not normal for me.

25/6/15 - Clomid 100mg CD2 75mg CD3-5 - 100mg CD6 - +opk CD 12! Ovitrelle Trigger CD12(midnight) - Scan CD13 - 4 Dominant Folls - 9/7/15 currently 3DPO! Totally unexpected cycle so far!

http://www.fertilityfriend.com/home/23b5d1/
kar1ene
 
Posts: 60
Joined: Thu Dec 18, 2014 9:07 pm

Re: New to Board - Hoping for Twins - Protocol help needed

Postby Bluerose26 » Thu Jan 08, 2015 11:37 pm

I've chosen to use the injectables to boost my chances of twins, clomid alone has quite low chances. Best thing is to read through everything you can, write a basic protocol and then keep tweeking it until your happy with it.
Image
CD1-BFP:
Folic acid 5mg
Pregnacare conception couple
Royal Jelly 500mg
CD1-O:
Evening primrose oil 1000mg x3 daily
CD2-CD7:
Clomid 25/50mg
CD5-CD6:
FSH 37.5iu. Folliculine/Bravelle
CD7-CD8-CD10:
FSH 75iu. Folliculine/Bravelle
5000 iu trigger (at positive opk)
1DPO-5DPO:
Bromalain (pineapple) 1500mg
1DPO-10weeks +:
Progesterone?
5DPO:
1-2000iu triggerx
Bluerose26
 
Posts: 25
Joined: Wed Nov 19, 2014 7:39 pm

Re: New to Board - Hoping for Twins - Protocol help needed

Postby kar1ene » Fri Jun 05, 2015 3:40 pm

Hi Again,

Ok so I started TTC Twins this month.

Clomid Days 5-9 100mg - 50mg on day 9 as began to get worried about Overstimulating when triggering?? (hot flushes at night and a bit vague headed at times) Robitussen 3 times daily.

Today is day 10 and glad no more clomid.

I plan to OPK daily from now, I have 2 Ovitrelle injections to trigger. Each pre-filled syringe contains 250 micrograms choriogonadotropin alfa* (equivalent to approximately 6,500 IU) in 0.5 mL solution

So I plan to take that on Day 13?14 which will be Monday Tuesday ? From what I have read most people take it with a positive OPK -

What is worrying me is doing the trigger (ovitrelle), I am wondering if I should trigger the whole injection or just half, bit afraid for overstimulation. But from reading other protocols, people seem to be fine. What has worried me - from the research, scans are usually carried out to see how many follicles, as if there are too many then it can cause hyperstimulation, so as I am unable to obtain a scan here and wont know, this is worrying me. Any advice?

I am wondering if I should trigger the full injection on +OPK and then 5 days later do a boost of half the other injection?? Although I have plenty of clomid, I had to get the Ovitrelle from a friend who travelled to Turkey and unable to obtain any more until at least August this year maybe, so scared to waste it.

Any thoughts?? Any cycle buddies around??

Thanks
27th May 15 - AF CD5-8 100mg Clomid, CD9 50mg Robitussen 3 x daily + OPK CD 15 - Ovitrelle 250mg(6500IUI) FF said ovulated CD 17 AF arrived CD29 not normal for me.

25/6/15 - Clomid 100mg CD2 75mg CD3-5 - 100mg CD6 - +opk CD 12! Ovitrelle Trigger CD12(midnight) - Scan CD13 - 4 Dominant Folls - 9/7/15 currently 3DPO! Totally unexpected cycle so far!

http://www.fertilityfriend.com/home/23b5d1/
kar1ene
 
Posts: 60
Joined: Thu Dec 18, 2014 9:07 pm

Re: New to Board - Hoping for Twins - Protocol help needed

Postby squinn313 » Fri Jun 05, 2015 4:53 pm

Don't have much advice about the trigger, but when I took 100mg clomid I ovulated late both months. Day 20 vs day 16 on a regular month. So just keep it in mind that clomid can sometimes push back ovulation. I think my doctor said ovulation should happen up to 10 days after your last pill.
2017:
Prenatal, Vit. D 10000, , B12, COQ10, folic acid 1200, Selinium, zinc, Sweet Cassava
Black Cohosh, Maca cd1-13
Femara 2.5mg cd3-7
Bromelain 1-5dpo
Estrace cd 3-12
EPO cd10-15
10,000iu trigger cd 15
Prometrium O+10days

I've returned after a long break! Ready to start again!!
squinn313
 
Posts: 206
Joined: Mon Dec 01, 2014 6:01 am

Re: New to Board - Hoping for Twins - Protocol help needed

Postby Dreamingoftwins » Fri Jun 05, 2015 6:18 pm

Hiya hun, I'm in the UK too... Can I ask where you got your trigger from as I'm in desperate need of one!

ETA. Ignore me I just saw you got it from a friend!

I think it's possible to get scans to check follicles from the likes of Babybond etc. I know my local Babybond do fertility scans including checking follicles and I think that's only about £99...
Dreamingoftwins
 
Posts: 373
Joined: Sun Mar 09, 2014 7:41 pm
Location: England

Re: New to Board - Hoping for Twins - Protocol help needed

Postby kar1ene » Fri Jun 05, 2015 10:14 pm

Hi dreaming of twins, I had a friend who was travelling in Turkey, and they managed to purchase it over the counter there without any scripts. I hope to go across this year and get some more in the summer if needed. Thanks for the info on the scans. I will look in to it. Which region of the UK are you?

Thanks for the info Squinn, will bear in mind.
27th May 15 - AF CD5-8 100mg Clomid, CD9 50mg Robitussen 3 x daily + OPK CD 15 - Ovitrelle 250mg(6500IUI) FF said ovulated CD 17 AF arrived CD29 not normal for me.

25/6/15 - Clomid 100mg CD2 75mg CD3-5 - 100mg CD6 - +opk CD 12! Ovitrelle Trigger CD12(midnight) - Scan CD13 - 4 Dominant Folls - 9/7/15 currently 3DPO! Totally unexpected cycle so far!

http://www.fertilityfriend.com/home/23b5d1/
kar1ene
 
Posts: 60
Joined: Thu Dec 18, 2014 9:07 pm

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